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This paper proposes a novel method that can predict protein interaction sites in heterocomplexes using residue spatial sequence profile and evolution rate approaches. The former represents the information of multiple sequence alignments while the latter corresponds to a residueÕs evolutionary conservation score based on a phylogenetic tree. Three predictors using a support vector machines algorithm are constructed to predict whether a surface residue is a part of a protein-protein interface.doi:10.1016/j.febslet.2005.11.081 pmid:16376878 fatcat:ysihizesqjgrbejt5fqzujqdp4