Clinical factors influencing the resting and stimulated salivary flow

Shigeo Yamachika, Ken Yamamoto, Yoshiaki Nomura, Hiroyuki Yamada, Ichiro Saito, Yoichi Nakagawa
2012 Open Journal of Stomatology  
Objective: The objective of this study was to examine the clinical and immunological factors influencing sialometry in xerostomia patients. Method: The association between sialometry and other clinical examinations were investigated in a cross-sectional study. A total of 179 dry mouth patients showing hyposalivation who underwent a clinical examination were enrolled in this study. Multiple regression analyses were employed to examine the relative contributions of clinical and immunological
more » ... immunological factors including age, gender, parotid sialography, labial Salivary gland biopsy, anti-Ro/SS-A antibodies, and anti-La/SS-B antibodies to the resting (RSF) or stimulated saliva flow rate (SSF). Results: An increase of the stage of sialography, the grade of a labial biopsy, and the presence of anti-La/SS-B antibody had a significant correlation with a decrease of sialometry. Results of the multiple regression analysis showed that age (standardized coefficient = −0.244), grade of lip biopsy (−0.189), and anti-SS-B antibody (−0.171), were significantly associated with the RSF. The stage of sialography (−0.423) and age (−0.169) were significantly related to the sialometry in the SSF according to a multiple regression analysis. Conclusion: The results of this study suggest that the measurement of RSF reflects the immunological factors and SSF reflects the damage to the parotid gland.
doi:10.4236/ojst.2012.22019 fatcat:wu76fsgcgrc6vkpwqdbfqhhtdy