Orientation of structure according to climatology plays a very important role in reducing the amount of carbon footprint in the environment.. This paper presents the effect of seismic load combining with vertical load on reinforced concrete structure orientated by 30⁰,45⁰,60⁰,90⁰ and 180⁰ degree keeping CG of structure same with respect to global x-z plane. A G+11 multi storey commercial building were analyzed in Staad pro v8i by orienting it in five different angles with respect to global x-z

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... lane and observed the behavior, performance and response of structure in terms of storey drift, displacement, bending moment and shear force. Results indicated that maximum storey drift in global "x" direction is more for structure oriented by 180⁰. Maximum top nodal displacement in global "x "direction is exceeding the permissible limit in all case except for the structure oriented by 90⁰ angle. Maximum bending moment was observed for structure oriented by 90⁰ and maximum shear force for structure oriented by 180⁰. Hence it is observed that the orientation of structure is important from environmental as well as design point of view. As height of structure go on increasing these design parameter values will also go on increasing.