Study aim: This study aimed to investigate the effect of aerobic training (AT) and pomegranate juice intake (PJI) on the lipid profile in men with type 2 diabetes. Materials and methods: This randomized clinical trial was performed in middle-aged men (40–50 years old) with type 2 diabetes. Participants were randomly assigned into four groups: AT + PJI (n = 9); AT (n = 10); PJI (n = 9), and control (C) (n = 10). The AT program consisted of 60-75% of HRMax, 40-60 min/day, three days/wk for eight

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... eeks. Participants in the PJI group consumed 240 ml of pomegranate juice (sugar or additive-free) daily for eight weeks. Lipid profile was measured at the beginning and end of the study. The data were analyzed through paired t-test and one-way analysis of variance, as well as Tukey's post hoc test at the signification level of P<0.05. Results: AT + PJI, PJI, and AT groups demonstrated significant improvements in lipid profile compared to the C group. The results show that the AT + PJI group had significantly lower TC and LDL (p = 0.001 and p = 0.002, respectively), and significantly higher HDL (p = 0.023) compared with the PJI group. There was no significant difference between AT and PJI groups. Also, TG was significantly lower in AT+ PJI compare to the C group. Conclusions: AT + PJI is more effective than AT or PJI alone in the improvement of lipid profile in patients with type 2 diabetes.