Prognostic role of neutrophil-to-lymphocyte ratio in patients with brain arteriovenous malformations

Sunfu Zhang, Jing Zhang, Qingqing Ren, Min He, Baoyin Shan, Yunhui Zeng, Zhiyong Liu, Hao Liu, Jianguo Xu
2015 OncoTarget  
Purpose: This study was to investigate the prognostic value of the neutrophil-tolymphocyte ratio (NLR) in patients with brain arteriovenous malformations (AVMs). Materials and Methods: Patients with AVMs were retrospectively identified. A hemogram from peripheral venous blood samples was taken within 24 hours of admission. The occurrences of death or major disability were noted at the end point of 6 months and the outcome was assessed with a modified Rankin Scale score. Results: A total of 175
more » ... ts: A total of 175 patients were enrolled. There were 97 (55%) patients in the ruptured AVMs group and 78 (45%) in the unruptured AVMs group. In patients with unruptured AVMs, NLR was an independent risk factor for poor outcome at 6 months (p = .036), but not a significant predictor with a ROC area of 0.638. Whereas, NLR was higher in the patients with poor outcome in ruptured AVMs group (p < .001). The area under the curve was .864 (P < .001), and an NLR of 8.88 was identified the best discriminating variable and the best predictive cutoff value. Conclusions: NLR represented a reliable prognostic predictor for patients with ruptured AVMs. However, the NLR could not be a useful prognostic predictor for patients presented with unruptured AVMs.
doi:10.18632/oncotarget.24236 fatcat:fe4h5uvy3vgkdo34tl4rtoba5m