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Specific insulin-like growth factor I (IGF-I) receptors on human promyelocytic leukemia cell line (HL-60) were identified and characterized. [125I]IGF-I specifically bound to the cells, and PIJIGF-I binding to the cells was displaced by unlabeled IGF-I in a dose dependent manner. [125I] IGF-I binding to the cells were displaced by multiplication stimulating activity (MSA) and porcine insulin, with potencies that were10and100times less than that of IGF-I, respectively. By an affinity labelingdoi:10.1507/endocrj1954.34.365 pmid:2958273 fatcat:km3vtncakzfzpgde36du44s26u