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No significant differences are found in efficacy comparisons of second-generation antidepressants, though physicians should consider varying frequency of side effects when developing treatment plans. When prescribing a second-generation antidepressant for treatment of major depression, it may be best to focus on side-effect profiles and onset of action, as new research suggests that the efficacy of these drugs is relatively comparable.doi:10.1176/pn.47.3.psychnews_47_3_20-a fatcat:osypkhzbhjfbnasmgrn5e7aj4e