1911 The Lancet  
hardly be taken as an explanation ; it means no more than that the multiplication of the parasites produces more parasites." From these remarks it is quite evident that our explanation of the increase and decrease of trypanosomes has been entirely misunderstood. In the first place, we do not disagree with the explanation of Massaglia, &c. ; in the second place, we do not give the alternative explanation that " the increase of parasites is due to their sudden and active development." We have, I
more » ... pment." We have, I think, given our explanation quite clearly in the last page of our article, which I cannot do better than quote, as follows :-It would seem, therefore, that the explanation may be reduced to some of the following causes, all of which mav come into play. 1. The increase of trypanosomes is due to their active multiplication, the rate of multiplication depAnding on the following conditions: (a) The liberation of a reproductive stimulant from the trypanosomes of the previous fall. (b) The small number of leucocytes, especially mononuclears. (c) The habituation of the trypanosomes to their antibodies. (d) The absence, or the diminution of antibodies to the trypanosomes. (a), (b), (c), and (d) are therefore our explanations of the increase of trypanosomes. (0) and (d) are Massaglia's explanations. (a) and (b) are, so far as we know, original further hypotheses put forward by Major Ross and myself.
doi:10.1016/s0140-6736(01)62722-3 fatcat:anfbcfnnebdprkj6yowlr2om6a