Article type: Case Report Cutaneous eruptions and arthralgia in children can occur after infections, drugs and immunologic processes via different mechanisms. This is a report of a 7 years old girl with a history of maculopapular rashes that changed to target-shaped lesions and pruritus with non-pitting edema of ankles, strawberry tongue and periungual scaling of extremities, with no history of any drug usage. She had elevated liver enzymes and positive anti-viral capsid antigen (VCA) (IgM and

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... gG), and depressed C3, C4 and CH50, that returned to normal after 3 months. Here we explain the states that could cause similar clinical scenario and discuss them briefly. Implication for health policy/practice/research/medical education: Skin eruptions and fever are common manifestations in pediatric group , complete physical exam and logical laboratory investigations helps us to correct diagnosis and prevent us from unnecessary drug administration.