EFFECT OF MERCURIC COMPOUNDS ON THE MATERNAL TRANSMISSION OF SELENIUM IN THE PREGNANT AND LACTATING RAT

J. PARIZEK, I. OSTDALOVA, J. KALOUSKOVA, A. BABICKY, L. PAVLIK, B. BIBR
1971 Reproduction  
The administration of small amounts of mercuric compounds to pregnant rats, injected with 75Se in the form of selenite, markedly increased their retention of 75Se and simultaneously decreased the 75Se content in their foetuses. The 75Se concentration in the blood and liver of foetuses from these rats was much lower than in the blood and liver of foetuses from control mothers injected with [75Se]selenite only (or receiving zinc chloride instead ofmercuric chloride). Retention of 75Se in the
more » ... nal organs and the passage of 75Se into the foetuses was partially dependent on the dose of mercury. In the doses used in these experiments, administration of mercuric salts did not result in foetal death nor in any significant effect on the weight of the offspring. In lactating rats, the administration ofmercuric salts had a similar effect on the passage of 75Se into the milk. This resulted in a much smaller 75Se content in the newborn and suckling young of mothers exposed to small amounts of mercuric compounds during pregnancy or lactation than in control animals. 157 158 J. Pafízek et al. selenium deficiency in the feed (Schwarz & Mertz, 1960; Schubert, Muth, Oldfield & Remmert, 1961; Hartley & Grant, 1961) . It seems reasonable to expect that during pregnancy and lactation, the interfering factors could act not only at the level of the availability of selenium for the maternal organism but also at the level of the transmission of selenium from the maternal organism into the foetuses and the milk. The administration of small amounts of salts of certain metals such as
doi:10.1530/jrf.0.0250157 pmid:5558377 fatcat:zrdhbfc4sfhxlptcv5tsig6qsa