Role of folate in nonalcoholic fatty liver disease

Victoria Sid, Yaw L. Siow, Karmin O
2017 Canadian Journal of Physiology and Pharmacology  
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver diseases that are characterized by steatosis (hepatic lipid accumulation), inflammation, fibrosis, and liver injury. Chronic consumption of high-fat diets is a major cause of obesity and NAFLD. Because NAFLD is a multifaceted disorder with many underlying metabolic abnormalities, currently, there is no pharmacological agent that is therapeutically approved for the treatment of NAFLD. Folate is a PUBLICATIONS Research
more » ... IONS Research articles: 1. Sid V, Siow YL, Shang Y, Woo CW, O K. High-fat diet consumption reduces hepatic folate transporter expression via nuclear respiratory factor-1. J Mol Med (Berl). 2018; 96(11):1203-1213. 2. Sid V, Shang Y, Siow YL, Madduma Hewage S, House JD, O K. Folic acid supplementation attenuates chronic hepatic inflammation in high-fat diet fed mice. Lipids. 2018; 53 (7):709-716. 3. Sid V, Siow, YL, O K. Role of folate in non-alcoholic fatty liver disease (NAFLD). Can J Physiol Pharmacol. 2018; 95(10):1141-1148. 4. Sarna LK, Sid V, Wang P, Siow YL, House JD, O K. Tyrosol attenuates high-fat dietinduced hepatic oxidative stress: potential involvement of cystathionine beta-synthase and cystathionine gamma-lyase. Lipids. 2016; 51(5):583-90. 5. Sid V, Wu N, Sarna LK, Siow YL, House JD, O K. Folic acid supplementation during highfat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism. Am J Physiol Regul Integr Comp Physiol. 2015; 309(10):R1215-25.
doi:10.1139/cjpp-2016-0681 pmid:28460180 fatcat:m4jn3ahbebhqjpcgahc5axgciy