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Fusion activity and inactivation of influenza virus: kinetics of low pH-induced fusion with cultured cells
Journal of General Virology
The kinetics of fusion of influenza virus (A/PR/8/34) with human promyelocytic leukaemia (HL-60), human T lymphocytic leukaemia (CEM) and murine lymphoma ($49) cells were investigated. Fusion was demonstrated by electron microscopy, and monitored by fluorescence dequenching of octadecylrhodamine incorporated in the virus membrane. Rapid fusion was induced upon mild acidification of the medium. At pH 5, all virus particles were capable of fusing with the cells. The initial rate and the extent ofdoi:10.1099/0022-1317-73-1-27 pmid:1730942 fatcat:fwimqyqfkzhsjenuwcb3llxjb4