Solid State Characterization of Ceftiofur Sodium Polymorph

B Sivakumar, K Suresh Kumar, S Mohan, U Senthilkumar
Journal of Chemical and Pharmaceutical Research   unpublished
The present study deals with the solid state characterization of novel Ceftiofur Sodium having moisture content in the range of 5.0-8.0%. Here the analytical challenge is to determine the exact hydration state, i.e. Dihydrate or Hemipentahydrate or Trihydrate. Based on the results of vacuum assisted PXRD, DSC, TGA, DVS and HSM the hydration state was confirmed as trihydrate wherein one mole in the lattice, forms channel hydrate and two moles are possibly present as ion-associated..
more » ... Ceftiofur Sodium (Figure 1), a third-generation cephalosporin antibiotic [1], is administered as an intramuscular injection for treatment of some respiratory diseases in beef cattle, diary cattle, swine and day-old chickens, and to treat interdigital dermatitis in cattle [2]. It has also been assessed for treatment of mastitis and other septic conditions in cattle [3]. The chemical designation is [6r-[6a,7b(z)]]-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl] amino]-3-[[2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid. The sodium and hydrochloride salts are administered intramuscularly and intravenously.
fatcat:to7febjn6nh4jav57qesbeqiqe