we implemented a simpler technique for administration of melphalan by preparing all doses in a total volume of 250 mL NS. This method yields concentrations between 0.45 to 2 mg/mL for patients of a BSA from 0.81 to 3.56 m 2 for 140 mg/m 2 doses and 0.57 to 2.5 m 2 for 200 mg/ m 2 doses. In a review of the first 30 autologous HCT patients who received melphalan 200 mg/m 2 via this method, median engraftment was on days 12 and 16 for neutrophils and platelets, respectfully, which is the same as

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... r historical data for this transplant regimen. To date this method has been used for over 350 transplant patients. This practice change simplified both pharmacy and nursing procedures such that all doses are dispensed in a single bag with a total volume of 250 mL and infused via one infusion pump at a standard rate of 500 mL/hour. This simplified compounding and administration of doses decreases time spent by both pharmacy and nursing for treatments using melphalan. The use of a single bag and one standard infusion rate also reduces the likelihood of administration errors by eliminating the need to calculate infusion rates and coordinate the use of multiple pumps.