Aim. The problem of birth control is one of the most pressing problems of modern society. That's why family planning and the creation of safe and reliable methods of contraception come to the fore. The aim of this work was to study the features of the mitotic regime of the endometrium when using silver-containing intrauterine contraceptive devices (IUDs), to assess the oncological risk in women who have been using this method of contraception for a long time (within 6 months - 7 years).

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... s and methods. Evaluation of the mitotic activity of endometrial and stromal cells in women who used silver-containing IUDs for different periods. The study involved 230 women who were divided into groups I (used IUDs for 6-12 months), II (for 1-3 years), III (for 3-5 years), IV (for 5-7 years) and the control group (51 women). Mitotic activity, the percentage ratio of the mitosis phases were determined in all groups. Results. During the study it was revealed that the mitotic activity of the endometrium at different periods of use of silver-containing IUDs did not change significantly. However, in women who used silver-containing IUDs for a long time, there was the increase in the number of mitoses with a predominance of the pathology of the same species as in the control group, which indicates the need for using IUDs for no more than 5 years. Keywords: silver-containing intrauterine contraceptive devices, mitotic activity, oncological risk, contraception.