Arsenic: Health Effects, Mechanisms of Actions, and Research Issues

Charles O. Abernathy, Yung-Pin Liu, David Longfellow, H. Vasken Aposhian, Barbara Beck, Bruce Fowler, Robert Goyer, Robert Menzer, Toby Rossman, Claudia Thompson, Michael Waalkes
1999 Environmental Health Perspectives  
A meeting on the health dfect of arsenic (As), its modes of action, and areas in need of future research was held in Hunt Valley, Maryland, on 22-24 September 1997. Exposure to As in drinking water has been associated with the devdopment of skin and interal cancers and noncarcinogenic effects such as diabetes, peripheral neuropathy, and cardiovacular diseases. There is little data on specific mechanism(s) of action for As, but a great deal of information on possible modes ofaction. Although
more » ... ction. Although arsenite [As(III)] can inhibit more than 200 enzymes, events underlying the induction of the noncarcinogenic effects of As are not understood. With respect to car-cinogenic4ty, As can affec DNA repair, methylation of DNA, and increase radical formation and activation of the protooncogene c-myn, but none of these potential wys have widespread acceptance as the principal etiologic event In addition, there are no accepted modes for the study of As-induced ogenesit At the final meeting session we considered research needs. Among the most important areas cited were a) As metabolism and its interaction with celiular constituents; 6) possible bioaccmulation ofAs; c) interactions with other metals; 4) effiects ofAs on genetic material; e) development of animal models and ceil systems to study effects ofAs; and Jp a better rerizaion of human exposures as related to health risks. Some of the barriers to Address correspondence to C.O. Abernathy, Office of Science and Technology (4304), Room 1037 East
doi:10.2307/3434403 fatcat:gm7i7v6hpzekxkmaqaihjjixxy