The implementation of the cluster policy of the region is closely connected with the level of development of the scientific and innovation infrastructure and the activity of the subjects of innovation activity in the region. The article assesses the level of activity of the scientific and innovation sphere in the context of the life cycle phases of innovative enterprises in the region. In Omsk region, the key tool of financial support for innovations at the seed stage is the UMNIC program of

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... Foundation for Assistance to Small Innovative Enterprises in the scientific and technical sphere. Over the whole history of the contest, more than 16 000 projects of young scientists worth more than 5 billion rubles have been supported at the federal level, over 1 000 small innovative enterprises have been created, more than 2 000 jobs. In the Omsk region from 2007 to 2018, 260 program winners were given the opportunity to grant their research and innovation projects for the amount of 106.4 million rubles. The distribution of competitive applications in the directions and years is not uniform: the greatest number of applications fell on the direction "New devices and hardware complexes", the smallest – "Modern materials and technologies for their creation". At the stage of establishment of the enterprise, from 2014 to 20017. in the Omsk region, 72 applications were submitted for the START program of the Innovation Support Fund, of which 12 were supported by the Fund. The main problem in the Omsk region, as in Russia as a whole, at this stage is the lack of commercial competencies and presentation skills of scientists and inventors. The paper describes and defines key principles for the development of innovative infrastructure in the region, identifies the factors that impede the development of innovation in the region, gives recommendations on the activities of scientific and technical policies that stimulate the creation of innovative infrastructure elements in the region.