Simple and feasible blood markers-as predictors of perinatal asphyxia
International Journal of Contemporary Pediatrics
The objective of this research work was to study the hematological parameters as predictors of perinatal asphyxia and to assess their correlation with severity. Setting: Postnatal Wards, Kamla Raja Hospital and SNCU, Department of Pediatrics, Kamla Raja Hospital, Gajra Raja Medical College, Gwalior. Design: A prospective case control study. Participants :100 cases and 100 controls enrolled based on the selection criteria, on day 1 of life.Methods: New born on day 1, who fits the selection
... the selection criteria was enrolled. Birth details, relevant perinatal history, findings on physical examination and systemic signs were recorded on a predesigned proforma. Staging was done and new born classified as HIE stage I, II or III. Cord blood samples were collected and results analysed. Results: This study included 100 cases and 100 controls. Presence of maternal illness and birth history were found to have significance (p value <0.001) when compared between cases and controls. Number of nucleated RBCs/100 WBCs were found to be 6±1.93 in HIE-I; 9.5±4.8 in HIE-II and 16.45±6.6 in HIE-III as compared to 5.9±3.6 among the controls. The results are found to be significant (p value <0.001). Mean value of hemoglobin found among the controls was 16±2.5. This was 17.4±2.18 in HIE-I; 17.45±1.8 in HIE-II and 15.5±3.07 in HIE-III. The results are significant on comparison between cases and controls and among cases (p value <0.015, <0.001 respectively). Mean value of hematocrit among the controls was 49.24±7.98. This was 52.5±6.57 in HIE-I;52.56±5.46 in HIE-II and 47.6±5.8 in HIE-III. The difference was significant (p value <0.001) when comparison was done among the cases. Value of total leucocyte count (TLC) among the controls was 14.14±4.15; 14.06±6.8 in HIE-I;15.8±5.6 in HIE-II; 21.14±7.90 in HIE-III. The results were significant (p value <0.001) when comparing cases with controls and cases among themselves. There was no correlation seen with platelet count. Polychromatophilia was found significant (p value <0.001) when compared between cases and controls and among cases themselves.Conclusions:Hematological parameters are altered in perinatal asphyxia and can be used to predict the severity and outcome.