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Analysis of posttranslational modifications of proteins by tandem mass spectrometry
2006
BioTechniques
Protein activity and turnover is tightly and dynamically regulated in living cells. Whereas the three-dimensional protein structure is predominantly determined by the amino acid sequence, posttranslational modification (PTM) of proteins modulates their molecular function and the spatial-temporal distribution in cells and tissues. Most PTMs can be detected by protein and peptide analysis by mass spectrometry (MS), either as a mass increment or a mass deficit relative to the nascent unmodified
doi:10.2144/000112201
pmid:16774123
fatcat:uczz5e2kprhbjmvjmi5pdh5i2q