ANTIBACTERIAL ACTIVITY OF KSHARASUTRA (MEDICATED SETONE), IN THE MANAGEMENT OF THE FISTULA IN ANO

A A J P Kumara, D L Jayaratne
2016 International Journal of Research in Ayurveda and Pharmacy  
Fistula in ano could be treated effectively with Ksharasutra, the surgical linen impregnated with special Ayurvedic medicine of alkaline in nature. There are different theories in existence claiming the mode of action of the thread in fistula in ano. Antibacterial activity of the Ksharasutra thread is one of it. Aim of this study is to identify the antibacterial activity of the Ksharasutra. Main objective is to determine the antibacterial activity by using Antibacterial Sensitive Test (ABST).
more » ... tive Test (ABST). The (ABST) test bacteria were Staphylococcus aureus, Streptococcus pyogens, Escherichia coli, and Pseudomonas aeuruginosa, isolated from fistula specimens (Clinical cultures), and the standard strains. The Ksharasutra extract (100 mg/ml) was aseptically introduced into respective agar wells. Amoxicillin (100 mg/ml) was used as the positive control and the kept 50 µl distilled water was for the negative controls. Inhibition zones of ≥7 mm diameters around the well were regarded as significant susceptibility of the organisms to the extract. One way anova used as statistical method to analysis the data. Higher Zone of inhibition was observed in the ksharasutra thread extract for Staphylococcus aureus, 33.33±0. Escherichia coli, 30.60±0.33, Streptococcus pyogen 24.005±0.57 and Pseudomonas.. aeruginosa, 9.66±0.33. Standard antibiotic possess relatively low Zone of inhibition compare to the ksharasutra thread extract. Antibacterial activity of Ksharasutra due to the presence of curcumin and some of the inorganic compounds in kshara Cu, Zn Ca etc. So the Ksharasutra possess significant (P<0.05) Antibacterial activity in contrast to the standard antibiotic.
doi:10.7897/2277-4343.074129 fatcat:x32aevas3bamlbhchstj3tw5pe