P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation

Verónica Latapiat, Felipe E. Rodríguez, Francisca Godoy, Felipe A. Montenegro, Nelson P. Barrera, Juan P. Huidobro-Toro
2017 Frontiers in Pharmacology  
increase in the ATP-gated currents. In summary, allosteric modulators caused additive ATP-gated currents; consistent with lateral fenestration enlargement. Energy calculations demonstrated a favorable transition of the holo receptor state following both allosteric modulators binding, as expected for allosteric interactions.
doi:10.3389/fphar.2017.00918 pmid:29326590 pmcid:PMC5737101 fatcat:fskjreivijf6vpieuo3tljgkjm