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increase in the ATP-gated currents. In summary, allosteric modulators caused additive ATP-gated currents; consistent with lateral fenestration enlargement. Energy calculations demonstrated a favorable transition of the holo receptor state following both allosteric modulators binding, as expected for allosteric interactions.doi:10.3389/fphar.2017.00918 pmid:29326590 pmcid:PMC5737101 fatcat:fskjreivijf6vpieuo3tljgkjm