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P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation
2017
Frontiers in Pharmacology
increase in the ATP-gated currents. In summary, allosteric modulators caused additive ATP-gated currents; consistent with lateral fenestration enlargement. Energy calculations demonstrated a favorable transition of the holo receptor state following both allosteric modulators binding, as expected for allosteric interactions.
doi:10.3389/fphar.2017.00918
pmid:29326590
pmcid:PMC5737101
fatcat:fskjreivijf6vpieuo3tljgkjm