Internet Archive Scholar

Reduced Accumulation of the Prion Pathogenic Protein (PrPsc) in Mice Spleen Post Inoculation with a Mixture of the Scrapie C506M3 Strain and Streptomycin

Aly Moussa
2014 Journal of Chromatography & Separation Techniques  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (411.9 kB)
https://web.archive.org/web/20200709022744/https://www.longdom.org/open-access/reduced-accumulation-of-the-prion-pathogenic-protein-prpsc-in-mice-spleen-post-inoculation-2157-7064.1000214.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL. The file type is application/pdf.

Citation: Moussa A (2014) Reduced Accumulation of the Prion Pathogenic Protein (PrP sc ) in Mice Spleen Post Inoculation with a Mixture of the Scrapie C506M3 Strain and Streptomycin. J Chromatograph Separat Techniq 5: 214. Abstract The hydrogen bond transfer between the two guanidine groups present on streptomycin and the different amino acids on the PrP sc peptides provoked changes of the surface electric charges and even probably affected the stability and induced a drop in the PrP sc
more » ... ity. These can explain the reduction to even absence of accumulated prion infectivity marker PrP sc observed at 45 days post intraperitonial inoculation of a mixture of streptomycin and infected mouse brain homogenate of the scrapie strain C506M3 compared to controls.
doi:10.4172/2157-7064.1000214 fatcat:xkewew3czjdx7h624c3m4tw3ke
Citation

Aly Moussa. "Reduced Accumulation of the Prion Pathogenic Protein (PrPsc) in Mice Spleen Post Inoculation with a Mixture of the Scrapie C506M3 Strain and Streptomycin." Journal of Chromatography & Separation Techniques 05.02 (2014)