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Notch signaling patterns Drosophila mesodermal segments by regulating the bHLH transcription factor twist
2004
Development
Preserved Fulltext
signaling targets two distinct 'Repressors of twist' -the proteins encoded by the Enhancer of split complex [E(spl)-C] and the HLH gene extra machrochaetae (emc). Hence, the patterning of Drosophila mesodermal segments relies on Notch signaling changing the activities of a network of bHLH transcriptional regulators, which, in turn, control mesodermal cell fate. Since this same cassette of Notch, Su(H) and bHLH regulators is active during vertebrate mesodermal segmentation and/or subdivision,
doi:10.1242/dev.01113
pmid:15128668
fatcat:2twc57n4rfe6viukljuvv5ygia