The Rise of the Nested Multicompartment Model in Synthetic Cell Research

Emiliano Altamura, Paola Albanese, Fabio Mavelli, Pasquale Stano
2021 Frontiers in Molecular Biosciences  
The attractiveness of the "bottom-up" approach as a viable route for constructing cell-like systems (Luisi, 2002; Stano, 2019) is clearly evident by the ever increasing number of international projects and initiatives dedicated to this fascinating research (Supplementary Text S1). Such cell-like systems, simply called "synthetic cells" (SCs), "artificial cells" or "protocells" (although with slighly different nuances of meaning) are compartment-based systems (often, but not only, liposomes),
more » ... able of mimicking some aspects of cell behavior in a range of manners, and can be variously conceived in terms of materials, designs, and scopes. Even if current SCs are not alive, there is a recognized optimism among practicioners about the contribution of this research to basic and applied science, and there is the bet it will become one of the most important biotechnologies in the near future,-not resembling anything existing before-for example in nanomedicine (
doi:10.3389/fmolb.2021.750576 pmid:34540903 pmcid:PMC8446550 fatcat:hxmj6y5smnhaxj6zpctblgxkjy