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G Protein Signaling Modulator-3 Inhibits the Inflammasome Activity of NLRP3
<span title="2014-09-30">2014</span>
<i title="American Society for Biochemistry & Molecular Biology (ASBMB)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mryncoafc5cxdicldzfm4vlsze" style="color: black;">Journal of Biological Chemistry</a>
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NLRP3 is a key regulator of innate inflammation and is linked to inflammatory diseases. Results: GPSM3 associates with NLRP3 and inhibits its function. Conclusion: GPSM3 specifically inhibits NLRP3-dependent inflammasome activity by interacting with its leucine-rich repeat domain. Significance: This association uncovers a putative new mechanism of NLRP3 control, linking a G protein modulator to NLRP3-dependent inflammatory diseases.
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