A framework for the evaluation of patients with congenital facial weakness

Bryn D. Webb, Irini Manoli, Elizabeth C. Engle, Ethylin W. Jabs
2021 Orphanet Journal of Rare Diseases  
AbstractThere is a broad differential for patients presenting with congenital facial weakness, and initial misdiagnosis unfortunately is common for this phenotypic presentation. Here we present a framework to guide evaluation of patients with congenital facial weakness disorders to enable accurate diagnosis. The core categories of causes of congenital facial weakness include: neurogenic, neuromuscular junction, myopathic, and other. This diagnostic algorithm is presented, and physical exam
more » ... derations, additional follow-up studies and/or consultations, and appropriate genetic testing are discussed in detail. This framework should enable clinical geneticists, neurologists, and other rare disease specialists to feel prepared when encountering this patient population and guide diagnosis, genetic counseling, and clinical care.
doi:10.1186/s13023-021-01736-1 pmid:33827624 fatcat:bb4n42wj4jb27gpyxzkwis5vdi