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PEG-coated irinotecan cationic liposomes improve the therapeutic efficacy of breast cancer in animals
European Review for Medical and Pharmacological Sciences
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females owing. This study aimed to construct a kind of PEG-coated irinotecan cationic liposomes for investigating its efficacy and mechanism of action in the treatment of breast cancer in preclinical models. Evaluations were performed on the MDA-MB231 breast cancer cells, the xenografted MDA-MB231 cancer cells in Female nude mice and Sprague-Dawley (SD) rat. The liposomes were characterized throughpmid:24379067 fatcat:urg2mgghvffbxlev5bmaldly74