Adult invasive pneumococcal disease pre- and peri-pneumococcal conjugate vaccine introduction in a tertiary hospital in Singapore

L.-Y. Hsu, S. W. Lui, J. L. Lee, H. M. M. Hedzlyn, D. H.-L. Kong, S. Shameen, N. P. M. Siti, W. Y. Tan, X. Y. Toh, T.-Y. Koh, T.-H. Koh
2009 Journal of Medical Microbiology  
Streptococcus pneumoniae isolates causing invasive disease at a large tertiary institute in Singapore from 2000 to 2007 were serotyped, with 84 (43.8 %) and 159 (82.8 %) isolates belonging to serotypes covered by the pneumococcal heptavalent conjugate and polysaccharide vaccines, respectively. All non-meningitis isolates were susceptible to penicillin, and the attributable mortality was 21.4 %. Patients who fulfilled the US Advisory Committee on Immunization Practices criteria for vaccination
more » ... th the pneumococcal polysaccharide vaccine comprised 74.0 % of the study cohort and had a significantly higher mortality risk. Abbreviations: ACIP, Advisory Committee on Immunization Practices; PCV7, heptavalent conjugate vaccine; PPV, 23-valent polysaccharide vaccine.
doi:10.1099/jmm.0.003764-0 pmid:19074659 fatcat:bunad4htc5hs7ih564cj2jityu