Effects of anesthetic agents and fasting duration on 18F-FDG biodistribution and insulin levels in tumor-bearing mice

Kyung-Han Lee, Bong-Ho Ko, Jin-Young Paik, Kyung-Ho Jung, Yearn Seong Choe, Yong Choi, Byung-Tae Kim
2005 Journal of Nuclear Medicine  
Xy/Ke anesthesia markedly elevates blood (18)F-FDG activity and reduces tumor uptake ratios through inhibition of insulin release in mice kept fasting 4 h, whereas pentobarbital induces a similar but less severe response through insulin resistance. These metabolic effects, however, are substantially attenuated after 20 h of fasting. Hence both the choice of anesthetic and the duration of fasting have important effects on (18)F-FDG kinetics and PET images of tumor-bearing mice and should be
more » ... and should be considered when such studies are performed.
pmid:16157537 fatcat:eoodal5xgjbqzhmkukyywaijji