Purpose: : To evaluate the efficacy of polarized light therapy in atopic dermatitis patients through measuring the changes in the skin thickness by ultrasonography. Methods: Active controlled trail, randomized, single blind design. 40 male patients with chronic atopic dermatitis were randomly split into two groups. The A group (20 patients) received Bioptron light therapy; B group (20 patients) received topical corticosteroid cream with (hydrocortisone 2.5%) only. Ultrasonography was used to

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... luate skin thickness and SCORAD index was used to clinically estimate the degree of atopic dermatitis (AD). Results: Comparing between two groups post treatment, skin thickness showed statistically nonsignificant difference between groups. Regarding SCORAD index there was statistically significant improvement in both group with better improvement in Polarized light group with percentage of improvement 518.6 % versus 260.7 % percentage of improvement in topical corticosteroids group. Conclusion: Polarized light therapy is a simple, safe and effective procedure in treatment of atopic dermatitis which could reduce the need of long-term use of topical corticosteroid and avoid its associated side effects.