Clinical and laboratory characteristics of severe fever with thrombocytopenia syndrome in Chinese patients

Yali Weng, Nian Chen, Yaping Han, Yiping Xing, Jun Li
2014 Brazilian Journal of Infectious Diseases  
Severe fever with thrombocytopenia syndrome (SFTS) associated with severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging infectious disease. 12 patients with severe fever with thrombocytopenia syndrome in our study were presented mainly with fever and severe malaise. The clinical manifestations typically became worse on the 6th or 7th day. The average fever time is 9.11 ± 1.54 days. Most of them had multiorgan dysfunction, and part of them had hemophagocytic
more » ... c lymphohistiocytosis histiocytosis (HLH). The characteristic laboratory findings in the early stage were the drop of white blood cells (WBC), platelets (PLT) and serum Ca++, while increase of aspartate amino transferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH). CD3+CD4+ were significantly decreased, while CD3-CD56+ were significantly increased, whereas CD3+CD8+ were constantly elevated throughout the disease course. Ten to 14 days after illness onset, symptoms were improved, accompanied by resolution of laboratory abnormalities. These results indicate that severe fever with thrombocytopenia syndrome has an acute onset and self-limited course. It is a systemic infection. The host immune response caused tissues and organs injury. The improvement of symptoms and laboratory tests is consistent with the elimination of the virus and recover of immune response. Further investigation should be done in order to better understand this disease and guide the clinical treatment. Accumulating clinical cases with fever, thrombocytopenia and multiorgan dysfunction have been reported in Jiangsu Province of China since middle 1990s. 1,2 In 2010, newly emerging patients with the same symptoms in Hubei, Henan provinces and several other provinces were reported, 3,4 and then a new virus named severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) was confirmed 5 by sequencing the whole genome of the virus. Viruses of the Bunyaviridae family are classified into five genera: Orthobunyavirus,
doi:10.1016/j.bjid.2013.05.011 pmid:24076112 fatcat:2ermqqav65bqzkcnsiz6xnu4bq