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Cardiac oxidative stress in acute and chronic isoproterenol-infused rats
2005
Cardiovascular Research
Objective: Sympathetic nervous system activity in the myocardium is increased in patients with heart failure. However, the in vivo mechanisms responsible for B-adrenoceptor-mediated cardiac hypertrophy or remodeling remain unclear. This study aimed to clarify the role of reactive oxygen species (ROS) in mitogen-activated protein (MAP) kinase activation and tissue remodeling of the heart of isoproterenol (ISO)-infused rats. Methods and results: Different doses of ISO (up to1000 ng/kg/min) were
doi:10.1016/j.cardiores.2004.08.013
pmid:15621051
fatcat:oa3amvodnnbqvhh67eaexezzbq