Solvent Free Microwave Accelerated Synthesis of Heterocyclic Thiazolidin-4-ones as Antimicrobial and Antifungal Agents

Kondapalli Venkata Gowri Chandra Sekhar, Vajja Sambasiva Rao, Aravalli Satish Reddy, Ravada Sunandini, V S A Kumar Satuluri
2010 Bulletin of the Korean Chemical Society (Print)  
A simple and efficient method has been developed for conversion of arenecarbaldehyde-3-methylquinoxalin-2-ylhydrazones to 3-(2-methylquinoxalin-3-yl)-2-(substitutedphenyl)thiazolidin-4-ones in good yields using microwave irradiation technique on silica as solid support under solvent free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, 1 H NMR, and mass spectroscopy. All the synthesized thiazolidinones were investigated for their
more » ... robial and antifungal activities. The results of the biological activities revealed that the compounds 3b, 3d, 3f and 3h exhibited excellent antibacterial activities while 3d and 3h exhibited good antifungal activity.
doi:10.5012/bkcs.2010.31.5.1219 fatcat:nwukb7cd7rf5zodyfdmlmsoshq