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Protein Deimination in the Rat Brain: Generation of Citrulline-Containing Proteins in Cerebrum Perfused with Oxygen-Deprived Media
2000
Biomedical research
The central nervous system contains the posttranslational modification enzyme, peptidylarginine deiminase (PAD; EC 3.5.3.15) type II. This enzyme catalyzes the deimination of arginine residues of proteins in a calcium ion-dependent manner, thereby, forming citrulline residues. Previously, we found postmortem deimination of glial fibrillary acidic protein in rat spinal cord. In the present study, therefore, we studied the deimination further as a possible cause of neurodegeneration in cerebrum.
doi:10.2220/biomedres.21.197
fatcat:ohr5wolkcrdmpoxdad7y7digxi