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Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure
Previous studies have shown that marked changes in myocardial mitochondrial structure and function occur in human cardiac failure. To further understand the cellular events and to clarify their role in the pathology of cardiac failure, we have examined mitochondrial enzymatic function and peptide content, and mitochondrial DNA (mtDNA) integrity in a canine model of pacing-induced cardiac failure. Methods: Myocardium and skeletal muscle tissues were evaluated for levels of respiratory complexdoi:10.1016/s0008-6363(01)00368-6 pmid:11557238 fatcat:4iqu4sz2zvctlph2h7zsh3eqqu