Qigong is widely acknowledged by Asian breast cancer survivors as a potent health-promoting physical activity. This study investigated the hypothesis that quality of life (QoL) in the Qigong group is better than the placebo (aerobic) or usual care group. Methods: 197 participants were randomly assigned to either the 8-week Qigong, Placebo or Usual care (control) group. Measurement taken at baseline and post-intervention included QoL, distress and fatigue. Analysis of Covariance (ANCOVA) and

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... kal Wallis were used to examine for differences between groups of the measurements. Results: 95 consented participants completed the 8 week trial. The adherence rate for Qigong group and placebo group were 63% and 65% respectively. Qigong group showed significant marginal improvement in QoL scores compared to placebo (mean difference=7.3 unit; p=0.036) and, compared to usual care (mean difference=6.7 unit; p=0.048) on Functional Assessment Cancer Therapy-Breast measure. No significant change in QoL scores between the placebo and usual care groups were found, and no significant differences in fatigue or distress at post intervention (8week). Conclusion: Cancer survivors who participated in Qigong had significantly better QOL than placebo group or control group. Qigong as a source of preferred physical activity for enhancing health and reducing all-cause mortality can be encouraged in the survivorship phase to assist better self-management of health and wellbeing. Participants Patients were identified from the UMMC breast cancer clinical database, per the inclusion criteria [ i) aged between 18 and 65 years; ii) had a primary diagnosis of early stage (I-II) breast cancer from 2007 to 2012; iii) had completed primary cancer treatment with no evidence of metastasis; and iv) were at least one year post-diagnosis] and exclusion criteria [i) having a medical contraindication to exercise; ii) a major medical condition such as epilepsy, uncontrolled hypertension, a major orthopaedic problem or acute cardiovascular disease (patients diagnosed within last 6 months and are still