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INCREASED DIHYDROFOLATE REDUCTASE SYNTHESIS IN DIPLOCOCCUS PNEUMONIAE FOLLOWING TRANSLATABLE ALTERATION OF THE STRUCTURAL GENE. I. GENOTYPE DERIVATION AND RECOMBINATIONAL ANALYSES
OST structural gene mutations, which are not of the "nonsense" or "frame-Mshift" type, are recognized solely by effects on some property of the corresponding gene product or enzyme. A number of these mutations in a gene of the L-arabinose operon in Escherichia co2i have also been found (ENGLESBERG 1961 ) to alter the rate of synthesis of the enzyme as well. This form of dual biochemical effect could be distinguished from effects on enzyme synthesis determined by nonsense" or "frameshift"doi:10.1093/genetics/61.2.293 fatcat:fxvmrdl3gbha3l2ohpo6dctj6u