Recently, nanotechnology considered one of the most frontiers in scientific sector, which increasingly attracted researchers' interest due to its variable and valuable applications in all areas. Synthesis of nanoparticles represents a promising era in therapeutical research that may lead to the development of new approaches in pharmaceutical studies. Selenium nanoparticles (SeNPs) share a status of high repute owing to their remarkable therapeutical potential. Biological synthesis of

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... -friendly SeNPs using plant extracts has emerged as the beneficial alternative approach to chemical synthesis. In this regard, we have synthesized biogenic SeNPs (PG-SeNPs) using pomegranate peels (PP) aqueous extract as a stabilizing and reducing agent. The PG-SeNPs were characterized and evaluated for their anti-Helicobacter pylori (H.pylori) and anti-stomach cancer potential. Transmission electron microscopy (TEM) confirmed the formation of biogenic PG-SeNPs. The PG-SeNPs were efficacious against H.pylori. The PG-SeNPs at sub-MIC values showed dose-dependent inhibition of biofilm formation. The anti-stomach cancer ability of the PG-SeNPs was evaluated against SNU-16 stomach cancer cells. As evident from the MTT results, PG-SeNPs significantly reduced the cell viability in a dose-dependent manner. Briefly, the PG-SeNPs evolved with synergistically emerged attributes that were effective H. pylori; moreover, the PG-SeNPs and Se/Cu composite embodies intriguing anticancer potential against stomach cancer cells.