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Structure elements can be predicted using the contact volume among protein residues
2021
Biophysics and Physicobiology
Previously, the structure elements of dihydrofolate reductase (DHFR) were determined using comprehen-sive Ala-insertion mutation analysis, which is assumed to be a kind of protein "building blocks." It is hypo-thesized that our comprehension of the structure elements could lead to understanding how an amino acid sequence dictates its tertiary structure. However, the comprehensive Ala-insertion mutation analysis is a time- and cost-consuming process and only a set of the DHFR structure elements
doi:10.2142/biophysico.bppb-v18.006
pmid:33954082
pmcid:PMC8049775
fatcat:6kik7rcjgjdhfca6b3n7ahxn4i