Altered default mode and affective network connectivity in stroke patients with and without dysphagia

S Li, M Zhou, B Yu, Z Ma, S Chen, Q Gong, L He, X Huang, S Lui, X Wang, D Zhou, C He
2014 Journal of Rehabilitation Medicine  
Objective: Neuroimaging studies in stroke patients provide substantial evidence for the involvement of widespread cortical and subcortical regions in the control of swallowing. Although the affective network and the default mode network are functionally related to "autonomic" and "volitional" swallowing, little is known about their functional changes in dysphagic stroke patients. Methods: Unbiased seeds functional connectivity analysis was used to study the connectivity patterns of these
more » ... rns of these restingstate networks. Resting-state functional magnetic resonance imaging was performed in stroke patients with (n = 12) and without dysphagia (n = 12). Results: Compared with healthy controls, stroke patients with and without dysphagia had decreased functional connectivity in the default mode network and the affective network. Moreover, stroke patients with dysphagia also had decreased functional connectivity in both the default mode network and the affective network relative to patients without dysphagia. Conclusion: The difference in the extent of impairment in the default mode network and affective network of stroke patients with and without dysphagia may lead to improved understanding of the neuropathophysiological mechanism and rehabilitation of dysphagia. Fig. 2. A) The functional connectivity pattern of the affective network (AN) included the amygdala, ventromedial profrontal cortex and perigenual cingulate cortex, which comprise a corticolimbic circuit. The stroke patients with dysphagia showed widely diffuse impairments on functional connectivity organization in the AN. B) Compared with the healthy controls (HC), a significantly decreased functional connectivity was found in stroke patients without and with dysphagia in perigenual cingulate cortex, bilateral amygdala, pallidum and putamen. The bilateral amygdalae were found to have marked increased functional connectivity in stroke patients without dysphagia than in with dysphagia. R: right; l: left. J Rehabil Med 46
doi:10.2340/16501977-1249 pmid:24213671 fatcat:qrn4voq56fdq7hfdueatogg5di