A Unani medicine has been practiced traditionally in Indian subcontinent since a very long time. A Unani drug Makoy or blacknight shade, botanically named as Solanum nigrum Linn. belongs to family Solanaceae cultivated throughout the country in dry parts, quite common in cultivated lands, road sides and gardens. The drug has two varieties, one is bearing black color fruit, and other one has reddish brown color fruit. In both varieties, black color fruits are toxic in nature. It is recommended

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... at the root bark should not to be given to pregnant women. The Unani physicians have prescribed Makoy in various ailments like ascites, piles and chronic cirrhosis of the liver, gonorrhoea, inflammatory swellings and chronic cirrhosis of the liver and spleen, rheumatic and gouty joints and various skin disorders. This drug has been used extensively for its various therapeutic purposes such that astringent, carminative, diuretic, anti inflammatory, anti microbial, hepatoprotective and analgesic. In this review, an effort has been made to provide information on medicinal properties of Makoy (Solanum nigrum) mentioned in Unani classical literature as well as in recent scientific studies. KEYWORDS: Makoy, Solanum nigrum, Unani drug, Enab-us-salab.