Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence
American Journal of Physiology. Endocrinology and Metabolism
fects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence. Am J Physiol Endocrinol Metab 280: E120-E129, 2001.-The effects of the polypeptide hormone prolactin (PRL) in the development and regulation of benign prostate hyperplasia (BPH) and also in prostate cancer are not very well characterized. This study examines the action of PRL, either alone or in association with androgens [testosterone (T) or dihydrotestosterone (DHT)], in the rat prostate gland. The effects
... PRL and androgens were investigated after 30 and 60 days in control, castrated, castrated with a substitutive implant of T or DHT, and shamoperated Wistar rats. To enhance PRL release, we induced hyperprolactinemia by administering chronic injections of sulpiride (40 mg ⅐ kg Ϫ1 ⅐ day Ϫ1 ). Chronic hyperprolactinemia induces enlargement and inflammation of the lateral rat prostate without any histological changes on ventral and dorsal lobes. We also demonstrate that hyperprolactinemia induces Bcl-2 overexpression in the lateral rat prostate and that this could inhibit the level of apoptosis. The in vivo model established here is a useful in vivo approach for studying the hormonal regulation of normal and pathological prostate development. prolactin; testosterone; dihydrotestosterone THE CONSTANT INCREASE IN LIFE EXPECTANCY has enhanced the incidence of benign prostate hyperplasia (BPH) and prostate cancer. In particular, prostate cancer is the * These authors contributed equally to this work.