Purpose: To investigate the effects of commodified growth factor products used clinically on fibrovascular ingrowth into porous polyethylene orbital implants. Methods: Porous polyethylene orbital implant sheets (Medpor ® ) soaked with Nepidermin (Easyef ® ), Trafermin (Fiblast ® ), and normal saline were implanted into the backs of 18 Sprague-Dawley rats. The degree of fibrovascular ingrowth as observed using a light microscope was compared 1 and 2 weeks after implantation and was calculated as

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... a percentage of the fibrovascular ingrowth length. Results: One week after implantation, the percentage of fibrovascular ingrowth length was 25.33 ± 5.43%, 22.56 ± 5.30%, and 21.78 ± 4.66% in the Easyef ® -, Fiblast ® -and normal saline-soaked groups. The degree of fibrovascularization was higher in the Easyef ® -soaked group than in the other groups (p = 0.020, 0.012). Two weeks after implantation, the degree of fibrovascularization was 98.33 ± 5.00%, 100.00 ± 0.00%, and 95.89 ± 4.57%, which was significantly higher in the Easyef ® -, and Fiblast ® -soaked groups than in normal saline-soaked group (p = 0.019, <0.001). Conclusions: Commodified growth factor products used in other areas selectively enhanced fibrovascular ingrowth to a greater degree and earlier in ophthalmic plastic and reconstructive surgery. J Korean Ophthalmol Soc 2014;55(9):1366-1371