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TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes
2022
Target of rapamycin complex 1 (TORC1) promotes biogenesis and inhibits degradation of ribosomes in response to nutrient availability. To ensure a basal supply of ribosomes, cells preserve a small pool of dormant ribosomes under nutrient-limited conditions. The regulation of dormant ribosomes is poorly characterized. Here, we show that upon inhibition of TORC1 by rapamycin or nitrogen starvation, Stm1 (suppressor of target of Myb protein 1) forms nontranslating, dormant 80S ribosomes.
doi:10.5451/unibas-ep89782
fatcat:qyvxbpnbqzgqbn7uzpqlryu6em