TOXICOLOGICAL SCREENING OF BALAJIRAKADI KVATHA CURNA (BLJ) ON THE BASIS OF LIVER AND KIDNEY FUNCTION IN ALBINO RAT PLASMA
International Journal of Research in Ayurveda and Pharmacy
The study was devised to evaluate the effect on liver and kidney in rats plasma after chronic administration of Balajirakadi Kvatha Curna (BLJ), a classical Ayurvedic preparation that was included in the Bangladesh National Formulary of Ayurvedic Medicine 1992. BLJ is widely used in cough. For the toxicological studies the drug was administered per oral route at a dose of 40 ml/kg of the body weight for 45 consecutive days. Eight-week old albino rats (Rattus novergicus) of both sexes, bred and
... aintained at the animal house in the Department of Pharmacy, Jahangirnagar University, were used for the experiment. All experiments on rats were carried out in absolute compliance with the ethical guide for care and use of laboratory animals. Forty rats were randomly grouped into four where one male and one female were treated as control group and others were used as test group. After chronic administration of BLJ to the both male and female rats a statistically very highly significant (p = 0.001) decrease of Bilirubin level in the plasma was noted in comparison to their control group. In the male rats there was a noticeable increase (p = 0.087) in the Creatinine and a very highly significant (p = 0.001) decrease in the Urea content in plasma. In the female rats there was a statistically a very highly significant decrease (p = 0.001) in creatinine and urea content in plasma. In addition, there was a statistically a very highly significant increase in the Uric acid content in the plasma of the male rats while a statistically significant decrease in the Uric acid content found in the plasma of female rats.