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An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity
2004
Marine Drugs
Preserved Fulltext
An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene-15R(α),16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin.
doi:10.3390/md201001
fatcat:2zp2l5k2nzemhbhsxbhgbkw4a4