Objective: To determine the effect of a biochemical parameter in chronic drug addict patients in Peshawar, Khyber Pukhtunkhwa. Materials and Methods: Blood samples of 90 drug addicts were randomly collected, 45 were hashish and 45 were heroin addicts. Drug addicts having hepatitis B and C infections were excluded from the study. Three milliliters of blood samples were collected in the lithium heparin tube using an aseptic technique for the determination of Alanine transaminase, Aspartate

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... inase, Triglycerides, and Cholesterol. Results: Cholesterol was significantly decreased (P=0.00) in the age group between 21 and 40 years followed by the age group less than 20 years (P=0.02). Liver enzymes were significantly elevated but, were more significant up to 40 years (P=0.00). Conclusion: Heroin and hashish affect liver function enzymes Alanine transaminase and aspartate transaminase and cause a reduction in cholesterol levels in individuals using drugs for a long period. Keywords: Alanine transaminase (ALT), Aspartate transaminase (AST), Triglycerides, and Cholesterol.