Generation of long, fully modified, and serum-resistant oligonucleotides by rolling circle amplification

Marcel Hollenstein
2015 Organic and biomolecular chemistry  
Nucleoside triphosphates modified at any level of the scaffold were shown to be compatible with the rolling circle amplification method. The combination of modified dNTPs and RCA enables the generation of long, fully modified, single-stranded DNA oligonucleotides.
doi:10.1039/c5ob01540e pmid:26273951 fatcat:5xgimdpf2bdpvfq36qd3gwplqq