GLY67ARG substitution in RSPO4 disrupts the WNT signaling pathway due to an abnormal binding pattern with LGRs leading to anonychia

Syed Irfan Raza, Abdul Khaliq Navid, Zainab Noor, Khadim Shah, Nasser Rashid Dar, Wasim Ahmad, Sajid Rashid
2017 RSC Advances  
R-Spondins regulate the WNT/β-catenin signaling pathway by interacting with leucine rich-repeat containing G-protein coupled receptors (LGR4–6).
doi:10.1039/c7ra00762k fatcat:h46uuqqivbgxve6yxjgiim4o3e