Is sildenafil effective for treating pulmonary hypertension after pediatric heart surgery?

S. G. Raja
2005 Interactive Cardiovascular and Thoracic Surgery  
surgery? Is sildenafil effective for treating pulmonary hypertension after pediatric heart http://icvts.ctsnetjournals.org/cgi/content/full/5/1/52 located on the World Wide Web at: The online version of this article, along with updated information and services, is 1569-9293. (ESCVS). Summary A best evidence topic in pediatric cardiac surgery was written according to a structured protocol. The question addressed was whether sildenafil was effective in treating postoperative pulmonary
more » ... lmonary hypertension after pediatric heart surgery. Altogether 28 papers were found using the reported search, of which three represented the best evidence to answer the clinical question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses were tabulated. We conclude that oral sildenafil may be useful in reducing pulmonary vascular resistance and can be considered for treatment of postoperative pulmonary hypertension after pediatric heart surgery. However, evidence from a large, multicenter, randomized controlled trial is needed to validate the safety and efficacy of sildenafil for use in postoperative pediatric cardiac surgical patients.
doi:10.1510/icvts.2005.123885 pmid:17670511 fatcat:ax3ihfnhqzbiddk6lslkj6jnom